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Nascobal - Clinical Pharmacology 12.1 Nascobal Mechanism of Action Vitamin B12 can be converted to coenzyme B12 in tissues, and as such is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine, a reaction which also requires folate

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The application of L-asparaginase as a plasma Gln-depleting agent with a clear therapeutic effect in solid tumors warrants further investigation

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Other Medications : The antibiotic chloramphenicol , gout medication colchicine , and aminosalicylic acid can also interfere with B12